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Volume 3, Issue 12

thrombophlebitis: a nosocomial multidrug-resistant disease? Open Access

Abstract

is a non- commensal bacterium with a wide range of pathogenicity. The identification of multidrug-resistant (MDR) is concerning because drug susceptibility testing is not usually performed in microbiology laboratories. There is no consensus yet on the treatment of septic thrombophlebitis in this situation.

We report here the first case of a quinquagenarian patient with a history of AIDS and fungic endocarditis, who was diagnosed with a nosocomial thrombophlebitis in the right jugular vein caused by . Bitherapy with daptomycin for 12 days and linezolid for 23 days was combined with a therapeutic anticoagulant. The follow-up included weekly cervical ultrasound controls. The efficiency of the treatment and the stability of the lesions allowed us to alleviate the medication with a prophylactic dose of anticoagulant. The patient was discharged from hospital and showed no signs of recurrence after 12 months.

The lack of consensus relative to the management of septic thrombophlebitis precludes the validation of a specific treatment for the condition. Our results suggest that a combination that includes removal of the medical device is needed. A total of 6 weeks of antibiotherapy should be applied, starting with 2 weeks of vancomycin or a combination of antibiotitherapy with daptomycin in order to reduce the bacterial load and avoid resistance. Six weeks of anticoagulation therapy is effective.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Corynebacterium , multidrug resistance and septic thrombophlebitis
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
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2021-12-17
2024-04-19
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References

  1. Bowstead TT, Santiago SM. Pleuropulmonary infection due to Corynebacterium striatum. Br J Dis Chest 1980; 74:198–200 [View Article] [PubMed]
     [Google Scholar]
  2. Chandran R, Puthukkichal DR, Suman E, Mangalore SK. Diphtheroids-important nosocomial pathogens. J Clin Diagn Res 2016; 10:DC28–DC31 [View Article] [PubMed]
     [Google Scholar]
  3. McMullen AR, Anderson N, Wallace MA, Shupe A, Burnham CA. When good bugs go bad: epidemiology and antimicrobial resistance profiles of Corynebacterium striatum, an emerging multidrug-resistant, opportunistic pathogen. Antimicrob Agents Chemother 2017; 61:e01111-17 [View Article] [PubMed]
     [Google Scholar]
  4. Poojary I, Kurian A, V A J, Devapriya J D, M A T. Corynebacterium species causing breast abscesses among patients attending a tertiary care hospital in Chennai, South India. Infect Dis (Lond) 2017; 49:528–531 [View Article] [PubMed]
     [Google Scholar]
  5. Lee PP, Ferguson DA, Sarubbi FA. Corynebacterium striatum: an underappreciated community and nosocomial pathogen. J Infect 2005; 50:338–343 [View Article] [PubMed]
     [Google Scholar]
  6. Watkins DA, Chahine A, Creger RJ, Jacobs MR, Lazarus HM. Corynebacterium striatum: a diphtheroid with pathogenic potential. Clin Infect Dis 1993; 17:21–25 [View Article] [PubMed]
     [Google Scholar]
  7. Molina Collada J, Rico Nieto A, Díaz de Bustamante Ussia M, Balsa Criado A. Septic arthritis in a native knee due to Corynebacterium striatum. Reumatol Clin (Engl Ed) 2018; 14:301–302 [View Article] [PubMed]
     [Google Scholar]
  8. Verma R, Kravitz GR. Corynebacterium striatum empyema and osteomyelitis in a patient with advanced rheumatoid arthritis. BMJ Case Rep 2016; 2016:bcr2016214691 [View Article] [PubMed]
     [Google Scholar]
  9. Yanai M, Ogasawasa M, Hayashi Y, Suzuki K, Takahashi H et al. Retrospective evaluation of the clinical characteristics associated with Corynebacterium species bacteremia. Braz J Infect Dis 2018; 22:24–29 [View Article] [PubMed]
     [Google Scholar]
  10. Werth BJ, Hahn WO, Butler-Wu SM, Rakita RM. Emergence of high-level daptomycin resistance in Corynebacterium striatum in two patients with left ventricular assist device infections. Microb Drug Resist 2016; 22:233–237 [View Article] [PubMed]
     [Google Scholar]
  11. Mattos-Guaraldi AL, Guimarães LC, Santos CS, Veras AAO, Carneiro AR et al. Draft genome sequence of Corynebacterium striatum 1961 BR-RJ/09, a multidrug-susceptible strain isolated from the urine of a hospitalized 37-year-old female patient. Genome Announc 2015; 3:e00869-15 [View Article] [PubMed]
     [Google Scholar]
  12. Hong HL, Koh HI, Lee AJ. Native valve endocarditis due to Corynebacterium striatum confirmed by 16S ribosomal RNA sequencing: a case report and literature review. Infect Chemother 2016; 48:239–245 [View Article] [PubMed]
     [Google Scholar]
  13. Denny KJ, Kumar A, Timsit J-. F, Laupland KB. Extra-cardiac endovascular infections in the critically ill. Intensive Care Med 2019; 10:1007
     [Google Scholar]
  14. Ramos JN, Souza C, Faria YV, da Silva EC, Veras JFC et al. Bloodstream and catheter-related infections due to different clones of multidrug-resistant and biofilm producer Corynebacterium striatum. BMC Infect Dis 2019; 19:672 [View Article] [PubMed]
     [Google Scholar]
  15. Tattevin P, Crémieux AC, Muller-Serieys C, Carbon C. Native valve endocarditis due to Corynebacterium striatum: first reported case of medical treatment alone. Clin Infect Dis 1996; 23:1330–1331 [View Article] [PubMed]
     [Google Scholar]
  16. Neemuchwala A, Soares D, Ravirajan V, Marchand-Austin A, Kus JV et al. In vitro antibiotic susceptibility pattern of non-diphtheriae Corynebacterium isolates in Ontario, Canada, from 2011 to 2016. Antimicrob Agents Chemother 2018; 62:e01776-17 [View Article] [PubMed]
     [Google Scholar]
  17. Brun-Buisson C, Abrouk F, Legrand P, Huet Y, Larabi S et al. Diagnosis of central venous catheter-related sepsis: critical level of quantitative tip cultures. Arch Intern Med 1987; May 1;147:873–877 [View Article] [PubMed]
     [Google Scholar]
  18. Wattiau P, Janssens M, Wauters G. Corynebacterium simulans sp. nov., a non-lipophilic, fermentative Corynebacterium. Int J Syst Evol Microbiol 2000; 50 Pt 1:347–353 [View Article] [PubMed]
     [Google Scholar]
  19. Coyle MB, Leonard RB, Nowowiejski DJ. Pursuit of the Corynebacterium striatum type strain. Int J Syst Bacteriol 1993; 43:848–851 [View Article] [PubMed]
     [Google Scholar]
  20. Chirinos JA, Garcia J, Alcaide ML, Toledo G, Baracco GJ et al. Septic thrombophlebitis: diagnosis and management. Am J Cardiovasc Drugs 2006; 6:9–14 [View Article] [PubMed]
     [Google Scholar]
  21. Wilson Dib R, Chaftari A-. M, Hachem RY, Yuan Y, Dandachi D et al. Catheter-Related Staphylococcus aureus bacteremia and septic thrombosis: the role of anticoagulation therapy and duration of intravenous antibiotic therapy. Open Forum Infect Dis 2018; 5:fy249 [View Article] [PubMed]
     [Google Scholar]
  22. Hagiya H, Kimura K, Okuno H, Hamaguchi S, Morii D et al. Bacteremia due to high-level daptomycin-resistant Corynebacterium striatum: A case report with genetic investigation. J Infect Chemother 2019; 25:906–908 [View Article] [PubMed]
     [Google Scholar]
  23. Shah M, Murillo JL. Successful treatment of Corynebacterium striatum endocarditis with daptomycin plus rifampin. Ann Pharmacother 2005; 39:1741–1744 [View Article] [PubMed]
     [Google Scholar]
  24. Martín MC, Melón O, Celada MM, Alvarez J, Méndez FJ et al. Septicaemia due to Corynebacterium striatum: molecular confirmation of entry via the skin. J Med Microbiol 2003; 52:599–602 [View Article] [PubMed]
     [Google Scholar]
  25. Datta P, Gupta V, Gupta M, Pal K, Chander J. Corynebacterium striatum, an emerging nosocomial pathogen: case reports. Infect Disord Drug Targets 2021; 21:301–303 [View Article] [PubMed]
     [Google Scholar]
  26. Jones RN, Fritsche TR, Sader HS, Goldstein BP. Antimicrobial spectrum and potency of dalbavancin tested against clinical isolates from Europe and North America (2003): initial results from an international surveillance protocol. J Chemother 2005; 17:593–600 [View Article] [PubMed]
     [Google Scholar]
  27. Rolston KVI, Wang W, Nesher L, Shelburne SA, Prince RA. In vitro activity of dalbavancin and five comparator agents against common and uncommon Gram-positive organisms isolated from cancer patients. J Antibiot 2015; 69:381–387 [View Article]
     [Google Scholar]
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Corynebacterium striatum thrombophlebitis: a nosocomial multidrug-resistant disease?
Access Microbiology 3, 000307 (2021); https://doi.org/10.1099/acmi.0.000307
/content/journal/acmi/10.1099/acmi.0.000307
/content/journal/acmi/10.1099/acmi.0.000307
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