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Volume 3, Issue 9

Disseminated sporotrichosis in a person with human immunodeficiency virus disease Open Access

Abstract

Disseminated sporotrichosis is an incapacitating infection caused by the dimorphic fungus . Because this condition may mimic the presentation of tuberculosis, syphilis and other bacterial infections, the diagnosis may be missed or delayed.

We describe a case of disseminated sporotrichosis in a patient with poorly controlled human immunodeficiency virus infection. The patient was initially treated for bacterial skin infections. The differential diagnosis also included tuberculosis and syphilis. Only after appropriate specimens had been sent for microbiological and histopathological investigations was the diagnosis of disseminated sporotrichosis made and appropriate treatment started. The patient showed a good clinical response to itraconazole.

This report highlights the importance of having a high index of suspicion of endemic mycoses when managing immunocompromised patients. The report also demonstrates that a delay in the diagnosis of sporotrichosis increases morbidity and results in unnecessary and inappropriate treatment with associated costs and adverse effects.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): disseminated sporotrichosis , human immunodeficiency virus , Sporothrix schenkii and sporotrichosis
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License. The Microbiology Society waived the open access fees for this article.
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2021-09-21
2024-04-20
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References

  1. Schenck B. On refractory subcutaneous abscesses caused by a fungus possibly related to sporotrichia. John Hopkins Hosp 1898; 9:286–290
     [Google Scholar]
  2. Chakrabarti A, Bonifaz A, Gutierrez-Galhardo MC, Mochizuki T, Li S. Global epidemiology of sporotrichosis. Med Mycol 2015; 53:3–14 [View Article] [PubMed]
     [Google Scholar]
  3. Orofino-Costa R, Macedo PM, Rodrigues AM, Bernardes-Engemann AR. Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics. An Bras Dermatol 2017; 92:606–620 [View Article] [PubMed]
     [Google Scholar]
  4. Govender NP, Maphanga TG, Zulu TG, Patel J, Walaza S et al. An outbreak of lymphocutaneous sporotrichosis among mine-workers in South Africa. PLoS Negl Trop Dis 2015; 9:e0004096 [View Article] [PubMed]
     [Google Scholar]
  5. Barros MB, de Almeida Paes R, Schubach AO. Sporothrix schenckii and Sporotrichosis. Clin Microbiol Rev 2011; 24:633–654 [View Article] [PubMed]
     [Google Scholar]
  6. Reinprayoon U, Jermjutitham M, Tirakunwichcha S, Banlunara W, Tulvatana W et al. Conjunctival sporotrichosis from cat to human: Case report. Am J Ophthalmol Case Rep 2020; 20:100898 [View Article] [PubMed]
     [Google Scholar]
  7. Conceição-Silva F, Morgado FN. Immunopathogenesis of human sporotrichosis: What we already know. J Fungi (Basel) 2018; 4:89 [View Article]
     [Google Scholar]
  8. Moreira JA, Freitas DF, Lamas CC. The impact of sporotrichosis in HIV-infected patients: a systematic review. Infection 2015; 43:267–276 [View Article] [PubMed]
     [Google Scholar]
  9. Queiroz-Telles F, Buccheri R, Benard G. Sporotrichosis in immunocompromised hosts. J Fungi 2019; 5:8 [View Article]
     [Google Scholar]
  10. Ferreira TA, Trope BM, Barreiros G, Quintela DC, Ramos-E-Silva M. Atypical manifestation of disseminated sporotrichosis in an AIDS patient. Case Rep Dermatol 2018; 10:231–237 [View Article] [PubMed]
     [Google Scholar]
  11. Bonifaz A, Tirado-Sánchez A. Cutaneous disseminated and extracutaneous sporotrichosis: current status of a complex disease. J Fungi 2017; 3:6 [View Article]
     [Google Scholar]
  12. Yap FB. Disseminated cutaneous sporotrichosis in an immunocompetent individual. Int J Infect Dis 2011; 15:e727–9 [View Article] [PubMed]
     [Google Scholar]
  13. He Y, Ma C, Fung M, Fitzmaurice S. Disseminated cutaneous sporotrichosis presenting as a necrotic facial mass: case and review. Dermatol Online J 2017; 23: [PubMed]
     [Google Scholar]
  14. White M, Adams L, Phan C, Erdag G, Totten M et al. Disseminated sporotrichosis following iatrogenic immunosuppression for suspected pyoderma gangrenosum. Lancet Infect Dis 2019; 19:e385–e391 [View Article] [PubMed]
     [Google Scholar]
  15. Lopes-Bezerra LM, Mora-Montes HM, Zhang Y, Nino-Vega G, Rodrigues AM et al. Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents. Med Mycol 2018; 56:126–143 [View Article] [PubMed]
     [Google Scholar]
  16. Rudramurthy SM, Chakrabarti A. Sporotrichosis: Update on diagnostic techniques. Curr Fungal Infect Rep 2017; 11:134–140 [View Article]
     [Google Scholar]
  17. Alvarez-Rivero V, Hernandez-Castro R, Moreno-Coutiño G, Lozano-Platonoff A. Disseminated sporotrichosis: an important differential diagnosis for venous ulcers. Adv Skin Wound Care 2020; 33:1–3 [View Article] [PubMed]
     [Google Scholar]
  18. Arenas R, Sánchez-Cardenas CD, Ramirez-Hobak L, Ruíz Arriaga LF, Vega Memije M. Sporotrichosis: from KOH to molecular biology. J Fungi 2018; 4:62 [View Article]
     [Google Scholar]
  19. Kauffman CA. Endemic mycoses: blastomycosis, histoplasmosis, and sporotrichosis. Infectious Disease Clinics of North America 2006; 20:645–662 [View Article]
     [Google Scholar]
  20. Kauffman CA, Bustamante B, Chapman SW, Pappas PG. Infectious Diseases Society of America Clinical practice guidelines for the management of sporotrichosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 2007; 45:1255–1265 [View Article] [PubMed]
     [Google Scholar]
  21. Carol AK, Rana H, Stanley WC. Practice guidelines for the management of patients with sporotrichosis. Clin Infect Dis 2000; 30:684–687
     [Google Scholar]
  22. Carol AK. Old and new therapies for sporotrichosis. Clin Infect Dis 1995; 21:981–985 [View Article] [PubMed]
     [Google Scholar]
  23. Willems L, Van der Geest R, De Beule K. Itraconazole oral solution and intravenous formulations: a review of pharmacokinetics and pharmacodynamics. J Clin Pharm Ther 2001; 26:159–169 [View Article] [PubMed]
     [Google Scholar]
  24. Rojas OC, Bonifaz A, Campos C, Treviño-Rangel RJ, González-Álvarez R et al. Molecular identification, antifungal susceptibility, and geographic origin of clinical strains of Sporothrix schenckii complex in Mexico. JoF 2018; 4:86 [View Article]
     [Google Scholar]
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Disseminated sporotrichosis in a person with human immunodeficiency virus disease
Access Microbiology 3, 000262 (2021); https://doi.org/10.1099/acmi.0.000262
/content/journal/acmi/10.1099/acmi.0.000262
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