1887

Abstract

is a common bacterial pathogen that causes acute otitis media (AOM) in children. In this study, we investigated nasopharyngeal carriage rates and serotype distributions of among school children with AOM in Banyumas Regency, Central Java, Indonesia, from 2018 to 2019. Nasopharyngeal swab specimens and demographic data were collected from 122 children between the ages of 6 and 12. The specimens were cultured for the identification of , and serotyping was performed using a sequential multiplex PCR assay. We found that the carriage rate was 73 % (89/122) among children with AOM. Serotypes 23A (11 %) and 6A/6B (10 %) were the most common serotypes among the 91 cultured strains, followed by 3 (8 %), 14 (7 %), 6C/6D (7 %), 11A/11D (6 %), 15B/15C (4 %) and 35 B (4 %). Moreover, 41 % of the strains could be covered by the 13-valent pneumococcal conjugate vaccine, PCV13. In conclusion, high nasopharyngeal carriage rates of were found in school children with AOM, with almost half of the strains being the vaccine-type. This finding provides a baseline for nasopharyngeal carriage of in school children with AOM and supports the implementation of pneumococcal conjugate vaccines in Indonesia.

Funding
This study was supported by the:
  • Kementerian Riset Teknologi Dan Pendidikan Tinggi Republik Indonesia (Award 176/SP2H/AMD/LT/DPRM/2020)
    • Principle Award Recipient: DanielJoko Wahyono
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2021-07-22
2021-07-29
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