Intrathecal daptomycin use in a challenging case of Enterococcus faecium ventriculitis

Ankush Dhariwal; Rachel Leff; Mike Allen; Benny Cherian

doi:10.1099/acmi.0.000230

Volume 4, Issue 4

Case Report

Open Access

Intrathecal daptomycin use in a challenging case of Enterococcus faecium ventriculitis

Ankush Dhariwal¹, Rachel Leff¹, Mike Allen² and Benny Cherian¹
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Affiliations: ¹ Barts Health NHS Trust, Royal London Hospital, Whitechapel Rd, London E1 1BB, UK ² Merck Sharp & Dohme (UK) Limited, 120 Moorgate, London, EC2M 6UR, UK
*Correspondence: Ankush Dhariwal, [email protected]
Published: 08 April 2022 https://doi.org/10.1099/acmi.0.000230

Abstract

Treatment of ventriculitis caused by enterococci can be challenging, and antibiotic options are limited. We describe a case of device-related ventriculitis caused by vancomycin-resistant Enterococcus faecium , refractory to initial antibiotics. Our management approach included intrathecal daptomycin. There were no attributable adverse events, and the patient remained infection-free following ventriculo-peritoneal shunt insertion and cessation of antibiotics.

Received: 02/03/2021
Accepted: 11/04/2021
Published Online: 08/04/2022

Keyword(s): daptomycin , Enterococcus faecium , external ventricular drain , intrathecal , ventriculitis and VRE

Funding

This study was supported by the:

nil (Award no funding received)
- Principle Award Recipient: AnkushDhariwal

This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.

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References

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Intrathecal daptomycin use in a challenging case of Enterococcus faecium ventriculitis

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Volume 4, Issue 4

Case Report

Open Access

Intrathecal daptomycin use in a challenging case of Enterococcus faecium ventriculitis

Abstract

Funding

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