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Volume 3, Issue 3

Oncogenic human papillomavirus in breast cancer: molecular prevalence in a group of Congolese patients Open Access

Abstract

Since the work of Band . in 1990 ( 87:463–467), several studies have suggested a possible link between the pathogenesis of breast cancer and viral infection. Infection with oncogenic HPV has been one of the viruses implicated in breast cancer cases worldwide.

To investigate the presence of HPV DNA in archived paraffin-embedded breast cancer cases at the University Hospital of Brazzaville and to assess the association between viral HPV infections and clinicopathological features.

A total of 40 formalin-fixed paraffin-embedded (FFPE) biopsies were retrospectively collected and available information was recorded. HPV detection and genotyping were performed by real-time PCR by GeneXpert technology (Cepheid, Sunnyvale, USA).

The mean age was 51.1±11.4 years (range 22–75 years; median was 47). Overall, HPV DNA was detected in six (15%) breast carcinoma samples. HPV-16, the most common genotype was identified in 83.7 % of all samples. HPV porting with clinicopathological features showed no significant difference (>0.05). However, a statistically significant difference was observed between HPV infection and SBR grade (=0.05).

Our study described a high prevalence of HPV-HR in breast cancer cases in the Congolese woman. Future type case-control studies are necessary to better describe the potential role of HPV in the occurrence of breast cancer in Congo.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): CHU-B , Congo , human breast cancer and human papillomavirus DNA
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
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2021-03-23
2024-04-25
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References

  1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68:394–424 [View Article] [PubMed]
     [Google Scholar]
  2. Kuchenbaecker KB, Hopper JL, Barnes DR, Phillips K-A, Mooij TM et al. Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA 2017; 317:2402–2416 [View Article] [PubMed]
     [Google Scholar]
  3. Richardson AK, Currie MJ, Robinson BA, Morrin H, Phung Y et al. Cytomegalovirus and Epstein–Barr virus in breast cancer. PLoS One 2015; 10:e0118989 [View Article] [PubMed]
     [Google Scholar]
  4. Naushad W, Surriya O, Sadia H. Prevalence of EBV, HPV and MMTV in Pakistani breast cancer patients: a possible etiological role of viruses in breast cancer. Infect Genet Evol 2017; 54:230–237 [View Article] [PubMed]
     [Google Scholar]
  5. Plummer M, de Martel C, Vignat J, Ferlay J, Bray F et al. Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob Health 2016; 4:e609–e616 [View Article] [PubMed]
     [Google Scholar]
  6. Oh J-K, Weiderpass E. Infection and cancer: global distribution and burden of diseases. Ann Glob Health 2014; 80:384–392 [View Article] [PubMed]
     [Google Scholar]
  7. Cavalcante JR, Pinheiro LGP, Almeida PRCde, Ferreira MVP, Cruz GA et al. Association of breast cancer with human papillomavirus (HPV) infection in northeast Brazil: molecular evidence. Clinics 2018; 73:e465 [View Article] [PubMed]
     [Google Scholar]
  8. Lawson JS, Salmons B, Glenn WK. Oncogenic viruses and breast cancer: mouse mammary tumor virus (MMTV), bovine leukemia virus (BLV), human papilloma virus (HPV), and Epstein–Barr virus (EBV). Front Oncol 2018; 8:1 [View Article] [PubMed]
     [Google Scholar]
  9. Band V, Zajchowski D, Kulesa V, Sager R. Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Proc Natl Acad Sci U S A 1990; 87:463–467 [View Article] [PubMed]
     [Google Scholar]
  10. Di Lonardo A, Venuti A, Marcante ML. Human papillomavirus in breast cancer. Breast Cancer Res Treat 1992; 21:95–100 [View Article]
     [Google Scholar]
  11. Global Burden of Disease Cancer Collaboration Fitzmaurice C, Dicker D, Pain A, Hamavid H et al. The global burden of cancer 2013. JAMA Oncol 2015; 1:505–527 [View Article] [PubMed]
     [Google Scholar]
  12. Wang T, Chang P, Wang L, Yao Q, Guo W et al. The role of human papillomavirus infection in breast cancer. Med Oncol 2012; 29:48–55 [View Article] [PubMed]
     [Google Scholar]
  13. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999; 189:12–19 [View Article] [PubMed]
     [Google Scholar]
  14. Casper C, Fitzmaurice C. Infection-Related cancers: prioritising an important and eliminable contributor to the global cancer burden. Lancet Glob Health 2016; 4:e580–e581 [View Article] [PubMed]
     [Google Scholar]
  15. Heng B, Glenn WK, Ye Y, Tran B, Delprado W et al. Human papilloma virus is associated with breast cancer. Br J Cancer 2009; 101:1345–1350 [View Article] [PubMed]
     [Google Scholar]
  16. Rabaan AA, Alfaraj SA, Alkhalifah MA. Comparison of the Cepheid Xpert HPV test and the HC2 high-risk HPV DNA test for detection of high-risk HPV infection in cervical smear samples in SurePath preservative fluid. J Med Microbiol 2018; 67:676–680 [View Article] [PubMed]
     [Google Scholar]
  17. Toliman P, Badman SG, Gabuzzi J, Silim S, Forereme L et al. Field evaluation of Xpert HPV point-of-care test for detection of human papillomavirus infection by use of self-collected vaginal and clinician-collected cervical specimens. J Clin Microbiol 2016; 54:1734–1737 [View Article] [PubMed]
     [Google Scholar]
  18. Cuzick J, Cuschieri K, Denton K, Hopkins M, Thorat MA et al. Performance of the Xpert HPV assay in women attending for cervical screening. Papillomavirus Res 2015; 1:32–37 [View Article]
     [Google Scholar]
  19. Guerendiain D, Moore C, Wells L, Conn B, Cuschieri K. Formalin fixed paraffin embedded (FFPE) material is amenable to HPV detection by the Xpert(®) HPV assay. J Clin Virol 2016; 77:55–59 [View Article] [PubMed]
     [Google Scholar]
  20. Donà MG, Rollo F, Pichi B, Spriano G, Pellini R et al. Evaluation of the Xpert® HPV assay in the detection of human papillomavirus in formalin-fixed paraffin-embedded oropharyngeal carcinomas. Oral Oncol 2017; 72:117–122 [View Article] [PubMed]
     [Google Scholar]
  21. Virtanen E, Laurila P, Hagström J, Nieminen P, Auvinen E. Testing for high-risk HPV in cervical and tonsillar paraffin-embedded tissue using a cartridge-based assay. APMIS 2017; 125:910–915 [View Article] [PubMed]
     [Google Scholar]
  22. Habyarimana T, Attaleb M, Mazarati JB, Bakri Y, El Mzibri M. Detection of human papillomavirus DNA in tumors from Rwandese breast cancer patients. Breast Cancer 2018; 25:127–133 [View Article] [PubMed]
     [Google Scholar]
  23. Simões PW, Medeiros LR, Simões Pires PD, Edelweiss MI, Rosa DD et al. Prevalence of human papillomavirus in breast cancer: a systematic review. Int J Gynecol Cancer 2012; 22:343–347 [View Article] [PubMed]
     [Google Scholar]
  24. Delgado-García S, Martínez-Escoriza J-C, Alba A, Martín-Bayón T-A, Ballester-Galiana H et al. Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study. BMC Cancer 2017; 17:320 [View Article] [PubMed]
     [Google Scholar]
  25. Bae J-M, Kim EH. Human papillomavirus infection and risk of breast cancer: a meta-analysis of case-control studies. Infect Agent Cancer 2016; 11:14 [View Article] [PubMed]
     [Google Scholar]
  26. Elamrani A, Ennaji MM, Benhessou M, Attaleb M, Mzibri M et al. Detection of human papillomavirus DNA in breast cancer in Moroccan woman. Annals of Oncology 2013; 24:iii45iii43 [View Article]
     [Google Scholar]
  27. Corbex M, Bouzbid S, Traverse-Glehen A, Aouras H, McKay-Chopin S et al. Prevalence of papillomaviruses, polyomaviruses, and herpesviruses in triple-negative and inflammatory breast tumors from algeria compared with other types of breast cancer tumors. PLoS One 2014; 9:e114559 [View Article] [PubMed]
     [Google Scholar]
  28. de León DC, Montiel DP, Nemcova J, Mykyskova I, Turcios E et al. Human papillomavirus (HPV) in breast tumors: prevalence in a group of Mexican patients. BMC Cancer 2009; 9:26 [View Article] [PubMed]
     [Google Scholar]
  29. Bzhalava D, Eklund C, Dillner J. International standardization and classification of human papillomavirus types. Virology 2015; 476:341–344 [View Article] [PubMed]
     [Google Scholar]
  30. de Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer 2017; 141:664–670 [View Article] [PubMed]
     [Google Scholar]
  31. Lindel K, Forster A, Altermatt HJ, Greiner R, Gruber G. Breast cancer and human papillomavirus (HPV) infection: no evidence of a viral etiology in a group of Swiss women. Breast 2007; 16:172–177 [View Article] [PubMed]
     [Google Scholar]
  32. Vernet-Tomas M, Mena M, Alemany L, Bravo I, De Sanjosé S et al. Human papillomavirus and breast cancer: no evidence of association in a Spanish set of cases. Anticancer Res 2015; 35:851–856 [PubMed]
     [Google Scholar]
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Oncogenic human papillomavirus in breast cancer: molecular prevalence in a group of Congolese patients
Access Microbiology 3, 000216 (2021); https://doi.org/10.1099/acmi.0.000216
/content/journal/acmi/10.1099/acmi.0.000216
/content/journal/acmi/10.1099/acmi.0.000216
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