1887

Abstract

Both bacterial and aseptic meningitis can complicate neurosurgery, but they are often difficult to distinguish clinically or by cerebrospinal fluid (CSF) analysis. We present an adolescent with subacute meningitis after neurosurgery, eventually diagnosed with meningitis caused by via 16S rRNA gene sequencing after two negative CSF cultures. He was treated successfully with intravenous meropenem with full recovery. This case shows that distinguishing bacterial from aseptic meningitis is important to allow directed antibiotic therapy. We recommend considering bacterial meningitis in the differential diagnosis of aseptic meningitis complicating neurosurgery, and to perform molecular diagnostics such as bacterial sequencing if the suspicion of bacterial meningitis is high.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
Loading

Article metrics loading...

/content/journal/acmi/10.1099/acmi.0.000213
2021-03-10
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/acmi/3/3/acmi000213.html?itemId=/content/journal/acmi/10.1099/acmi.0.000213&mimeType=html&fmt=ahah

References

  1. Forgacs P, Geyer CA, Freidberg SR. Characterization of chemical meningitis after neurological surgery. Clin Infect Dis 2001; 32:179–185 [View Article] [PubMed]
    [Google Scholar]
  2. Druel B, Vandenesch F, Greenland T, Verneau V, Grando J et al. Aseptic meningitis after neurosurgery: a demonstration of bacterial involvement. Clin Microbiol Infect 1996; 1:230–234 [View Article] [PubMed]
    [Google Scholar]
  3. Rihs JD, Brenner DJ, Weaver RE, Steigerwalt AG, Hollis DG et al. Roseomonas, a new genus associated with bacteremia and other human infections. J Clin Microbiol 1993; 31:3275–3283 [View Article] [PubMed]
    [Google Scholar]
  4. Romano-Bertrand S, Bourdier A, Aujoulat F, Michon A-L, Masnou A et al. Skin microbiota is the main reservoir of Roseomonas mucosa, an emerging opportunistic pathogen so far assumed to be environmental. Clin Microbiol Infect 2016; 22:737.e1–73737 [View Article] [PubMed]
    [Google Scholar]
  5. Schrag SJ, Farley MM, Petit S, Reingold A, Weston EJ et al. Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014. Pediatrics 2016; 138:e20162013 [View Article] [PubMed]
    [Google Scholar]
  6. Nolan JS, Waites KB. Nosocomial ventriculitis due to Roseomonas gilardii complicating subarachnoid haemorrhage. J Infect 2005; 50:244–251 [View Article] [PubMed]
    [Google Scholar]
  7. Devi U, Bora R, Malik V, Deori R, Gogoi B et al. Bacterial aetiology of neonatal meningitis: a study from north-east India. Indian J Med Res 2017; 145:138-143 [View Article] [PubMed]
    [Google Scholar]
  8. Wayne PA. Performance Standards for Antimicrobial Susceptibility Testing, CLSI Supplement M100. Clinical and Laboratory Standards Institute; 2019
    [Google Scholar]
  9. Gomez CA, Budvytiene I, Zemek AJ, Banaei N. Performance of targeted fungal sequencing for culture-independent diagnosis of invasive fungal disease. Clin Infect Dis 2017; 65:2035–2041 [View Article] [PubMed]
    [Google Scholar]
  10. Zbinden A, Böttger EC, Bosshard PP, Zbinden R. Evaluation of the colorimetric Vitek 2 card for identification of gram-negative nonfermentative rods: comparison to 16S rRNA gene sequencing. J Clin Microbiol 2007; 45:2270–2273 [View Article] [PubMed]
    [Google Scholar]
  11. McClelland S, Hall WA. Postoperative central nervous system infection: incidence and associated factors in 2111 neurosurgical procedures. Clin Infect Dis 2007; 45:55–59 [View Article] [PubMed]
    [Google Scholar]
  12. Han XY, Pham AS, Tarrand JJ, Rolston KV, Helsel LO et al. Bacteriologic characterization of 36 strains of Roseomonas species and proposal of Roseomonas mucosa sp nov and Roseomonas gilardii subsp rosea subsp nov. Am J Clin Pathol 2003; 120:256–264 [View Article] [PubMed]
    [Google Scholar]
  13. Fanella S, Schantz D, Karlowsky J, Rubinstein E. Septic arthritis due to Roseomonas gilardii in an immunocompetent adolescent. J Med Microbiol 2009; 58:1514–1516 [View Article] [PubMed]
    [Google Scholar]
  14. De I, Rolston KVI, Han XY. Clinical significance of Roseomonas species isolated from catheter and blood samples: analysis of 36 cases in patients with cancer. Clin Infect Dis 2004; 38:1579–1584 [View Article] [PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/acmi/10.1099/acmi.0.000213
Loading
/content/journal/acmi/10.1099/acmi.0.000213
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error