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Volume 2, Issue 8

A treated case of rhinocerebral zygomycosis with aspergillosis: a case report from India Open Access

Abstract

Zygomycosis and aspergillosis are two serious fungal infections that are commonly seen in immunocompromised patients. Since both of these infections involve fungi that invade vessels of the arterial system, an early and rapid diagnosis by direct examination of KOH mounts of the relevant clinical sample can clinch the diagnosis. Here, we present a case of a 60-year-old diabetic patient who presented with swelling and pain over the nose and left eye for 7 days with loss of vision in the left eye. After investigation, the patient was diagnosed as having rhinocerebral mucormycosis and aspergillosis, and was initially treated with amphotericin B (1 mg kg day intravenously), followed by endoscopic debridement under general anaesthesia. The patient gradually improved after surgery, and treatment with intravenous amphotericin B was continued along with the addition of 200 mg oral voriconazole twice daily (for the aspergillosis). With prompt diagnosis and treatment, the patient survived these fatal fungal co-infections and finally was discharged.

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Keyword(s): Amphotericin B , aspergillosis and mucormycosis
© 2020 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License. The Microbiology Society waived the open access fees for this article.
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2020-06-17
2024-04-23
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References

  1. Mackenzie JJ. Preliminary report on Aspergillus mycosis of the antrum maxillare. Johns Hopkins Hospital Bulletin 1893; 4:9–10
     [Google Scholar]
  2. Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen SCA, Dannaoui E et al. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis 2019; 19:e405–e421 [View Article][PubMed]
     [Google Scholar]
  3. Kwon-Chung KJ. Taxonomy of fungi causing mucormycosis and entomophthoramycosis (zygomycosis) and nomenclature of the disease: molecular mycologic perspectives. Clin Infect Dis 2012; 54 (Suppl. 1):S8–S15 [View Article][PubMed]
     [Google Scholar]
  4. Prabhu RM, Patel R. Mucormycosis and entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment. Clin Microbiol Infect 2004; 10 (Suppl. 1):31–47 [View Article][PubMed]
     [Google Scholar]
  5. Onyango JF, Kayima JK, Owen WO. Rhinocerebral mucormycosis: case report. East Afr Med J 2002; 79:390–393 [View Article][PubMed]
     [Google Scholar]
  6. Sharma OP, Chwogule R. Many faces of pulmonary aspergillosis. Eur Respir J 1998; 12:705–715 [View Article][PubMed]
     [Google Scholar]
  7. Warder FR, Chikes PG, Hudson WR. Aspergillosis of the paranasal sinuses. Arch Otolaryngol 1975; 101:683–685 [View Article][PubMed]
     [Google Scholar]
  8. Dayananda BC, Vandana R, Rekha K, Kumar GS. Aspergillosis of the maxillary antrum: a case report. J Oral Maxillofac Pathol 2002; 1:26–29
     [Google Scholar]
  9. Vaidya D, Shah P. Coinfection by Aspergillus and zygomycetes species in a case of acute rhinosinusitis. Case Rep Otolaryngol 2011; 2011:382473 [View Article][PubMed]
     [Google Scholar]
  10. Baeesa SS, Bokhari RF, Alghamdi KB, Alem HB, Al-Maghrabi JA et al. Invasive aspergillus sinusitis with orbitocranial extension. Asian J Neurosurg 2017; 12:172–179 [View Article][PubMed]
     [Google Scholar]
  11. Earhart KC, Baugh WP. Rhinocerebral mucormycosis. eMedicine Journal ( www.emedicine.com/med/topic2026.htm) (accessed 24 April 2008);; 2006
  12. van Dam AP, Pruijm MTC, Harinck BIJ, Gelinck LBS, Kuijper EJ. Pneumonia involving Aspergillus and Rhizopus spp. after a near-drowning incident with subsequent Nocardia cyriacigeorgici and N. farcinica coinfection as a late complication. Eur J Clin Microbiol Infect Dis 2005; 24:61–64 [View Article][PubMed]
     [Google Scholar]
  13. Mahomed S, Basanth S, Mlisana K. The successful use of amphotericin B followed by oral posaconazole in a rare case of invasive fungal sinusitis caused by co-infection with mucormycosis and aspergillus. IDCases 2015; 2:116–117 [View Article][PubMed]
     [Google Scholar]
  14. Malhotra S, Duggal S, Bhatia NK, Sharma N, Hans C. Rhinocerebral zygomycosis with pulmonary aspergillosis in a non-HIV-infected patient: an unusual case report from India. J Med Microbiol 2009; 58:146–150 [View Article][PubMed]
     [Google Scholar]
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A treated case of rhinocerebral zygomycosis with aspergillosis: a case report from India
Access Microbiology 2, e000139 (2020); https://doi.org/10.1099/acmi.0.000139
/content/journal/acmi/10.1099/acmi.0.000139
/content/journal/acmi/10.1099/acmi.0.000139
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