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Abstract

Phaeohyphomycosis is caused by a large, heterogeneous group of darkly pigmented fungi. It is an infrequent infection in humans. However, the prevalence has been increasing in recent years especially in immunocompromised patients. is a common black fungal pathogen of plants, which rarely causes human infection. We report the first case of cutaneous infection caused by in an immunocompetent host and the first in Asia. Although, the review of the literature revealed two previous cases of cutaneous infection caused by this organism, both of them were in immunocompromised hosts. A slow-growing asymptomatic nodule was the major clinical feature. Histopathological examination showed granulomatous inflammation and pigmented septate hyphae and yeast-like cells. The fungal isolation was identified by morphological characteristics and DNA sequencing. The lesion was resolved after complete surgical excision and oral fluconazole for two months. This report highlights the potential role of as an emerging cause of infection in immunocompetent patients.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
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/content/journal/acmi/10.1099/acmi.0.000128
2020-04-21
2024-04-16
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References

  1. Bolognia JL, Schaffer JV, Cerroni L. Dermatology, 4th ed. London, UK: Elsevier Health Sciences; 2017
    [Google Scholar]
  2. Caviedes MP, Torre AC, Eliceche ML, Valdivia Monteros DC, Volonteri VI et al. Cutaneous phaeohyphomycosis. Int J Dermatol 2017; 56:415–420 [View Article][PubMed]
    [Google Scholar]
  3. Benson DA, Cavanaugh M, Clark K, Karsch-Mizrachi I, Lipman DJ et al. Genbank. Nucleic Acids Res 2013; 41:D36–D42 [View Article][PubMed]
    [Google Scholar]
  4. Revankar SG, Baddley JW, Chen SC-A, Kauffman CA, Slavin M et al. A mycoses study group international prospective study of phaeohyphomycosis: an analysis of 99 Proven/Probable cases. Open Forum Infect Dis 2017; 4:ofx200 [View Article][PubMed]
    [Google Scholar]
  5. Revankar SG, Sutton DA. Melanized fungi in human disease. Clin Microbiol Rev 2010; 23:884–928 [View Article][PubMed]
    [Google Scholar]
  6. Silveira F, Nucci M. Emergence of black moulds in fungal disease: epidemiology and therapy. Curr Opin Infect Dis 2001; 14:679–684 [View Article][PubMed]
    [Google Scholar]
  7. Jacobson ES. Pathogenic roles for fungal melanins. Clin Microbiol Rev 2000; 13:708–717 [View Article][PubMed]
    [Google Scholar]
  8. Tirico MCCP, Neto CF, Cruz LL, Mendes-Sousa AF, Valkinir DEJ et al. Clinical spectrum of phaeohyphomycosis in solid organ transplant recipients. JAAD Case Rep 2016; 2:465–469 [View Article][PubMed]
    [Google Scholar]
  9. Thomas E, Bertolotti A, Barreau A, Klisnick J, Tournebize P et al. From phaeohyphomycosis to disseminated chromoblastomycosis: a retrospective study of infections caused by dematiaceous fungi. Med Mal Infect 2018; 48:278–285 [View Article][PubMed]
    [Google Scholar]
  10. Iriart X, Binois R, Fior A, Blanchet D, Berry A et al. Eumycetoma caused by Diaporthe phaseolorum (Phomopsis phaseoli): a case report and a mini-review of Diaporthe/Phomopsis spp invasive infections in humans. Clin Microbiol Infect 2011; 17:1492–1494 [View Article][PubMed]
    [Google Scholar]
  11. Mattei AS, Severo CB, Guazzelli LS, Oliveira FM, Gené J et al. Cutaneous infection by Diaporthe phaseolorum in Brazil. Med Mycol Case Rep 2013; 2:85–87 [View Article][PubMed]
    [Google Scholar]
  12. Sutton DA, Timm WD, Morgan-Jones G, Rinaldi MG. Human phaeohyphomycotic osteomyelitis caused by the coelomycete Phomopsis saccardo 1905: criteria for identification, case history, and therapy. J Clin Microbiol 1999; 37:807–811 [View Article][PubMed]
    [Google Scholar]
  13. Mandell KJ, Colby KA. Penetrating keratoplasty for invasive fungal keratitis resulting from a thorn injury involving Phomopsis species. Cornea 2009; 28:1167–1169 [View Article][PubMed]
    [Google Scholar]
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