@article{mbs:/content/journal/acmi/10.1099/acmi.0.000087, author = "Shepherd, S. J. and Sykes, C. and Jackson, C. and Bell, D. J. and Gunson, R. N.", title = "The first case of HIV-2 in Scotland", journal= "Access Microbiology", year = "2020", volume = "2", number = "3", pages = "", doi = "https://doi.org/10.1099/acmi.0.000087", url = "https://www.microbiologyresearch.org/content/journal/acmi/10.1099/acmi.0.000087", publisher = "Microbiology Society", issn = "2516-8290", type = "Journal Article", keywords = "HIV2", keywords = "treatment", keywords = "antiretrovirals", keywords = "diagnosis", eid = "e000087", abstract = "HIV-1 infects an estimated 37 million people worldwide, while the rarer HIV-2 infects 1–2 million worldwide. HIV-2 is mainly restricted to West African countries. The majority of patients in Scotland are diagnosed with HIV-1, but in 2013 the West of Scotland Specialist Virology Centre (WoSSVC) diagnosed Scotland’s first HIV-2 positive case in a patient from Côte d’Ivoire. HIV-2 differs from HIV-1 in terms of structural viral proteins, viral transmissibility, prolonged period of latency, intrinsic resistance to certain antivirals and how to monitor the effectiveness of treatment. Over the course of 5 years the patient has required several changes in treatment due to both side effects and pill burden. This case highlights the complexity of HIV-2 patient management over time.", }