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The first case of HIV-2 in Scotland Open Access

Abstract

HIV-1 infects an estimated 37 million people worldwide, while the rarer HIV-2 infects 1–2 million worldwide. HIV-2 is mainly restricted to West African countries. The majority of patients in Scotland are diagnosed with HIV-1, but in 2013 the West of Scotland Specialist Virology Centre (WoSSVC) diagnosed Scotland’s first HIV-2 positive case in a patient from Côte d’Ivoire. HIV-2 differs from HIV-1 in terms of structural viral proteins, viral transmissibility, prolonged period of latency, intrinsic resistance to certain antivirals and how to monitor the effectiveness of treatment. Over the course of 5 years the patient has required several changes in treatment due to both side effects and pill burden. This case highlights the complexity of HIV-2 patient management over time.

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Keyword(s): HIV2 , treatment , antiretrovirals and diagnosis
© 2019 The Authors
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2019-12-10
2020-01-24
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References

  1. Sharp PM, Hahn BH. Origins of HIV and the AIDS pandemic. Cold Spring Harb Perspect Med 2011;1: a006841 [CrossRef]
    [Google Scholar]
  2. Visseaux B, Damond F, Matheron S, Descamps D, Charpentier C et al. HIV-2 molecular epidemiology. Infect Genet Evol 2016;46: 233– 240 [CrossRef]
    [Google Scholar]
  3. Fonquernie L, Eholié SP, Damond F, Lacombe K, Girard P-M et al. Failure of HIV-2 viral load assay in a severely immunodeficient patient: clinical and therapeutic management issues. Trans R Soc Trop Med Hyg 2006;100: 282– 284 [CrossRef]
    [Google Scholar]
  4. Smith SM, Christian D, de Lame V, Shah U, Austin L et al. Isolation of a new HIV-2 group in the US. Retrovirology 2008;5: 103 [CrossRef]
    [Google Scholar]
  5. Ibe S, Yokomaku Y, Shiino T, Tanaka R, Hattori J et al. Hiv-2 CRF01_AB: first circulating recombinant form of HIV-2. J Acquir Immune Defic Syndr 2010;54: 241– 247 [CrossRef]
    [Google Scholar]
  6. Gottlieb GS, Hawes SE, Agne HD, Stern JE, Critchlow CW et al. Lower levels of HIV RNA in semen in HIV-2 compared with HIV-1 infection: implications for differences in transmission. AIDS 2006;20: 895– 890 [CrossRef]
    [Google Scholar]
  7. Hawes SE, Sow PS, Stern JE, Critchlow CW, Gottlieb GS et al. Lower levels of HIV-2 than HIV-1 in the female genital tract: correlates and longitudinal assessment of viral shedding. AIDS 2008;22: 2517– 2525 [CrossRef]
    [Google Scholar]
  8. Donnelly C, Leisenring W, Kanki P, Awerbuch T, Sandberg S et al. Comparison of transmission rates of HIV-1 and HIV-2 in a cohort of prostitutes in Senegal. Bull Math Biol 1993;55: 731– 743 [CrossRef]
    [Google Scholar]
  9. Piedade J, Venenno T, Prieto E, Albuquerque R, Esteves A et al. Longstanding presence of HIV-2 infection in Guinea-Bissau (West Africa). Acta Trop 2000;76: 119– 124 [CrossRef]
    [Google Scholar]
  10. Fryer HR, Van Tienen C, Van Der Loeff MS, Aaby P, Da Silva ZJ et al. Predicting the extinction of HIV-2 in rural Guinea-Bissau. AIDS 2015;29: 2479– 2486 [CrossRef]
    [Google Scholar]
  11. Evans LA, Moreau J, Odehouri K, Seto D, Thomson-Honnebier G et al. Simultaneous isolation of HIV-1 and HIV-2 from an AIDS patient. Lancet 1988;2: 1389– 1391 [CrossRef]
    [Google Scholar]
  12. Smallman-Raynor M, Cliff A. The spread of human immunodeficiency virus type 2 into Europe: a geographical analysis. Int J Epidemiol 1991;20: 480– 489 [CrossRef]
    [Google Scholar]
  13. Faria NR, Hodges-Mameletzis I, Silva JC, Rodés B, Erasmus S et al. Phylogeographical footprint of colonial history in the global dispersal of human immunodeficiency virus type 2 group A. J Gen Virol 2012;93: 889– 899 [CrossRef]
    [Google Scholar]
  14. Rübsamen-Waigmann H, Briesen HV, Maniar JK, Rao PK, Scholz C et al. Spread of HIV-2 in India. Lancet 1991;337: 550– 551 [CrossRef]
    [Google Scholar]
  15. Kannangai R, Ramalingam S, Castillo RC, Babu PG, John TJ et al. Hiv-2 status in southern India. Trans R Soc Trop Med Hyg 1999;93: 30– 31 [CrossRef]
    [Google Scholar]
  16. Valadas E, França L, Sousa S, Antunes F. 20 years of HIV-2 infection in Portugal: trends and changes in epidemiology. Clin Infect Dis 2009;48: 1166– 1167 [CrossRef]
    [Google Scholar]
  17. de Mendoza C, Cabezas T, Caballero E, Requena S, Amengual MJ et al. Hiv type 2 epidemic in Spain: challenges and missing opportunities. AIDS 2017;31: 1353– 1362 [CrossRef]
    [Google Scholar]
  18. Elamin W, Biddy DF, Clark DA, Anderson J, Deayton JR. HIV-2 in the United Kingdom - the North-East London cohort. HIV Med 2013;14: 131
    [Google Scholar]
  19. Gilleece Y, Chadwick DR, Breuer J, Hawkins D, Smit E et al. British HIV association guidelines for antiretroviral treatment of HIV-2-positive individuals 2010. HIV Med 2010;11: 611– 619 [CrossRef]
    [Google Scholar]
  20. Ren J, Bird LE, Chamberlain PP, Stewart-Jones GB, Stuart DI et al. Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors. Proc Natl Acad Sci U S A 2002;99: 14410– 14415 [CrossRef]
    [Google Scholar]
  21. Damond F, Benard A, Balotta C, Böni J, Cotten M et al. An international collaboration to standardize HIV-2 viral load assays: results from the 2009 ACHI(E)V(2E) quality control study. J Clin Microbiol 2011;49: 3491– 3497 [CrossRef]
    [Google Scholar]
  22. Malloch L, Kadivar K, Putz J, Levett PN, Tang J et al. Comparative evaluation of the Bio-Rad Geenius HIV-1/2 confirmatory assay and the Bio-Rad Multispot HIV-1/2 rapid test as an alternative differentiation assay for CLSI M53 algorithm-I. J Clin Virol 2013;58S: e85– e91 [CrossRef]
    [Google Scholar]
  23. Montesinos I, Eykmans J, Delforge M-L. Evaluation of the Bio-Rad Geenius HIV-1/2 test as a confirmatory assay. J Clin Virol 2014;60: 399– 401 [CrossRef]
    [Google Scholar]
  24. Hønge BL, Jespersen S, Medina C, Té DS, da Silva ZJ et al. The challenge of discriminating between HIV-1, HIV-2 and HIV-1/2 dual infections. HIV Med 2018;19: 403– 410 [CrossRef]
    [Google Scholar]
  25. van der Loeff MFS, Larke N, Kaye S, Berry N, Ariyoshi K et al. Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village. Retrovirology 2010;7: 46 [CrossRef]
    [Google Scholar]
  26. Delarue S, Didier E, Damond F, Ponscarme D, Brengle-Pesce K et al. Highly sensitive plasma RNA quantification by real-time PCR in HIV-2 group A and group B infection. J Clin Virol 2013;58: 461– 467 [CrossRef]
    [Google Scholar]
  27. Tchounga B, Ekouevi DK, Balestre E, Dabis F. Mortality and survival patterns of people living with HIV-2. Curr Opin HIV AIDS 2016;11: 537– 544 [CrossRef]
    [Google Scholar]
  28. Hansmann A, Schim van der Loeff MF, Kaye S, Awasana AA, Sarge-Njie R et al. Baseline plasma viral load and CD4 cell percentage predict survival in HIV-1- and HIV-2-infected women in a community-based cohort in the Gambia. J Acquir Immune Defic Syndr 2005;38: 335– 341
    [Google Scholar]
  29. Onyango CO, Leligdowicz A, Yokoyama M, Sato H, Song H et al. Hiv-2 capsids distinguish high and low virus load patients in a West African community cohort. Vaccine 2010;28: B60– B67 [CrossRef]
    [Google Scholar]
  30. Styer LM, Miller TT, Parker MM. Validation and clinical use of a sensitive HIV-2 viral load assay that uses a whole virus internal control. J Clin Virol 2013;58: e127– e133 [CrossRef]
    [Google Scholar]
  31. Matheron S, Damond F, Benard A, Taieb A, Campa P et al. Cd4 cell recovery in treated HIV-2-infected adults is lower than expected: results from the French ANRS CO5 HIV-2 cohort. AIDS 2006;20: 459– 462 [CrossRef]
    [Google Scholar]
  32. Camacho RJ. Special aspects of the treatment of HIV-2-infected patients. Intervirology 2012;55: 179– 183 [CrossRef]
    [Google Scholar]
  33. Clutter DS, Jordan MR, Bertagnolio S, Shafer RW. Hiv-1 drug resistance and resistance testing. Infect Genet Evol 2016;46: 292– 307 [CrossRef]
    [Google Scholar]
  34. Ekouevi DK, Tchounga BK, Coffie PA, Tegbe J, Anderson AM et al. Antiretroviral therapy response among HIV-2 infected patients: a systematic review. BMC Infect Dis 2014;14: 461 [CrossRef]
    [Google Scholar]
  35. Menéndez-Arias L, Alvarez M. Antiretroviral therapy and drug resistance in human immunodeficiency virus type 2 infection. Antiviral Res 2014;102: 70– 86 [CrossRef]
    [Google Scholar]
  36. Smith RA, Anderson DJ, Pyrak CL, Preston BD, Gottlieb GS et al. Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistance. J Infect Dis 2009;199: 1323– 1326 [CrossRef]
    [Google Scholar]
  37. Charpentier C, Camacho R, Ruelle J, Eberle J, Gürtler L et al. HIV-2EU-Supporting standardized HIV-2 drug-resistance interpretation in Europe: an update. Clin Infect Dis 2015;61: 1346– 1347 [CrossRef]
    [Google Scholar]
  38. Benard A, van Sighem A, Taieb A, Valadas E, Ruelle J et al. Immunovirological response to triple nucleotide reverse-transcriptase inhibitors and ritonavir-boosted protease inhibitors in treatment-naive HIV-2-infected patients: the ACHIEV2E collaboration Study Group. Clin Infect Dis 2011;52: 1257– 1266 [CrossRef]
    [Google Scholar]
  39. Boffito M, Jackson A, Pozniak A, Giraudon M, Kulkarni R et al. Effect of a modified saquinavir/ritonavir dosing regimen with lower dose lead-in phase on QTc interval, pharmacokinetics, antiviral activity and safety in treatment-naïve HIV-1-infected patients. Drugs R D 2015;15: 141– 153 [CrossRef]
    [Google Scholar]
  40. Ray AS, Fordyce MW, Hitchcock MJM. Tenofovir alafenamide: a novel prodrug of tenofovir for the treatment of human immunodeficiency virus. Antiviral Res 2016;125: 63– 70 [CrossRef]
    [Google Scholar]
  41. Bercoff DP, Triqueneaux P, Lambert C, Oumar AA, Ternes A-M et al. Polymorphisms of HIV-2 integrase and selection of resistance to raltegravir. Retrovirology 2010;7: 98 [CrossRef]
    [Google Scholar]
  42. Gottlieb GS, Smith RA, Dia Badiane NM, Ba S, Hawes SE et al. Hiv-2 integrase variation in integrase inhibitor-naïve adults in Senegal, West Africa. PLoS One 2011;6: e22204 [CrossRef]
    [Google Scholar]
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The first case of HIV-2 in Scotland
Microbiology Society , acmi000087; https://doi.org/10.1099/acmi.0.000087
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