1887

Abstract

is a common laboratory and environmental contaminant. Reports of severe infections are mainly limited to immunocompromised individuals. In reported cases, the time interval between bacteraemia and neuro-invasion appears to be very short, highlighting the importance of rapid and definitive identification and susceptibility testing of invasive . We report a case of a neonatal bacteraemia complicated by a brain abscess from a neonatal intensive care unit. The neonate presented with bradycardia and desaturations with increased oxygen requirements. Initial blood culture detected but was considered a contaminant. Repeated culturing of the Gram-positive rod was subsequently considered to be significant. Initial ultrasound head scans revealed echogenicity in the right posterior deep white matter. A large central cavity (5 mm diameter) could eventually be observed. The brain abscess resolved after surgical drainage and an extensive 6 weeks of antimicrobial therapy. This case study describes a rare event that illustrates the importance of rapid identification and susceptibility testing of invasive isolates from immunocompromised patients.

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2019-11-27
2019-12-11
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References

  1. Bottone EJ. Bacillus cereus, a volatile human pathogen. Clin Microbiol Rev 2010;23: 382– 398 [CrossRef]
    [Google Scholar]
  2. Glasset B, Herbin S, Granier SA, Cavalié L, Lafeuille E et al. Bacillus cereus, a serious cause of nosocomial infections: epidemiologic and genetic survey. PLoS One 2018;13: e0194346 [CrossRef]
    [Google Scholar]
  3. Hansford JR, Phillips M, Cole C, Francis J, Blyth CC et al. Bacillus cereus bacteremia and multiple brain abscesses during acute lymphoblastic leukemia induction therapy. J Pediatr Hematol Oncol 2014;36: e197– e201 [CrossRef]
    [Google Scholar]
  4. Drazin D, Lehman D, Danielpour M. Successful surgical drainage and aggressive medical therapy in a preterm neonate with Bacillus cereus meningitis. Pediatr Neurosurg 2010;46: 466– 471 [CrossRef]
    [Google Scholar]
  5. Clinical Laboratory and Standards Institute Methods for Antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria: Approved Guideline –, Second Edition. CLSI document M45-A2. Wayne, PA, USA: Clinical and Laboratory Standards Institute; 2010
    [Google Scholar]
  6. Tokieda K, Morikawa Y, Maeyama K, Mori K, Ikeda K. Clinical manifestations of Bacillus cereus meningitis in newborn infants. J Paediatr Child Health 1999;35: 582– 584 [CrossRef]
    [Google Scholar]
  7. Horii T, Tamai K, Notake S, Yanagisawa H. Bacillus cereus bloodstream infection in a preterm neonate complicated by late meningitis. Case Rep Infect Dis 2012;2012: 358789
    [Google Scholar]
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