%0 Journal Article %A Gren, Caroline %A Spiegelhauer, Malene Roed %A Rotbain, Emelie Curovic %A Ehmsen, Boje Kvorning %A Kampmann, Peter %A Andersen, Leif Percival %T Ruminococcus gnavus bacteraemia in a patient with multiple haematological malignancies %D 2019 %J Access Microbiology, %V 1 %N 8 %@ 2516-8290 %C e000048 %R https://doi.org/10.1099/acmi.0.000048 %K MALDI-TOF MS, gut commensals %K Ruminococcus gnavus %K hematology %K Microbiology %K Bacteremia %I Microbiology Society, %X We present a case of Ruminococcus gnavus sepsis in a woman suffering from multiple myeloma and myelodysplastic syndrome. R. gnavus , a Gram-positive coccus and a gut commensal, has been described in nine cases of infection in the literature, with most infections having occurred in patients with either gastrointestinal symptoms or prosthesis infections. In this case, R gnavus was identified by mass spectrometry, and showed susceptibility to penicillin, meropenem, tetracycline, metronidazole and clindamycin. The patient was successfully treated initially with intravenous piperacillin/tazobactam and metronidazole, and then switched to oral penicillin and metronidazole. The cause of infection is hypothesized to have been a shift in the gut microbiota towards an excess growth of R. gnavus caused by immunosuppression, and bacterial translocation across a vulnerable mucosal barrier due to prednisolone treatment and severe thrombocytopenia. %U https://www.microbiologyresearch.org/content/journal/acmi/10.1099/acmi.0.000048