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Volume 1, Issue 7

Antiphospholipid antibody syndrome with thrombotic splenic infarcts associated with acute cytomegalovirus infection Open Access

Abstract

We describe a case of acute cytomegalovirus (CMV) infection complicated by acquired antiphospholipid antibodies and splenic thrombi. We discuss the associations between CMV infection and thrombosis risk and correlation with antiphospolipid antibodies.

A previously healthy 32-year-old woman is hospitalized for acute abdominal pain and fever and found to have multiple splenic infarcts on an abdominal computed tomography (CT) scan. An infectious work-up is negative except for acute CMV, and a hypercoagulable work-up is only positive for antiphospholipid antibodies. The patient is discharged and placed on anti-coagulation therapy for 6 months.

Co-incident thrombosis and antiphospholipid antibody syndrome can occur with acute viral infections, including CMV. We discuss the viral infection-associated increased risk of developing blood clots and antiphospholipid antibodies as being either correlative with or causative of viral-induced thrombosis.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): acute CMV infection , anti-coagulation , antiphospholipid antibodies , antiphospholipid antibody syndrome and thrombosis
© 2019 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2019-09-01
2024-04-19
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Antiphospholipid antibody syndrome with thrombotic splenic infarcts associated with acute cytomegalovirus infection
Access Microbiology 1, e000032 (2019); https://doi.org/10.1099/acmi.0.000032
/content/journal/acmi/10.1099/acmi.0.000032
/content/journal/acmi/10.1099/acmi.0.000032
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