1887

Abstract

SUMMARY

Persistent infection by the retrovirus caprine arthritis-encephalitis virus (CAEV) induces arthritis in goats which closely resembles rheumatoid arthritis. To examine the relationship between virus expression and development of clinical disease, ten goat kids were inoculated with CAEV and examined at successive intervals through 18 months post-infection. Virus was monitored in cell-free synovial fluid cells, serum and peripheral blood cells by titration, co-cultivation and immunofluorescent techniques. Virus was readily recovered from the synovial cavity of all animals during the first 4 weeks of infection, followed by a reduction and fluctuation in virus titres and ability to detect virus. Recovery of CAEV from peripheral blood cells occurred at low frequency while viraemia was rare. Results obtained over a period of 18 months indicate a positive association between virus expression in the synovial cavity and development of clinically detectable disease.

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1984-09-01
2024-04-23
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References

  1. Adams D. S., Crawford T. B., Klevjer-Anderson P. 1980; A pathogenetic study of the early connective tissue lesions of viral caprine arthritis-encephalitis. American Journal of Pathology 99:257–278
    [Google Scholar]
  2. Adams D. S., Klevjer-Anderson P., Carlson J. L., McGuire T. C., Gorham J. R. 1983; Transmission and control of caprine arthritis-encephalitis virus. American Journal of Veterinary Research 44:1670–1675
    [Google Scholar]
  3. Anderson L. W., Klevjer-Anderson P., Liggett H. D. 1983a; Susceptibility of blood-derived monocytes and macrophages to caprine arthritis-encephalitis virus. Infection and Immunity 41:837–840
    [Google Scholar]
  4. Anderson L. W., Klevjer-Anderson P., McGuire T. C. 1983b; Immune rabbit sera do not recognize antigenic variants of CAEV isolated during persistent infection. Infection and Immunity 42:845–847
    [Google Scholar]
  5. Banks K. L., Greenlee A. 1982; Lymphocyte subpopulations of the goat: isolation and identification. American Journal of Veterinary Research 43:314–317
    [Google Scholar]
  6. Brahic M., Stowring L., Ventura P., Haase A. T. 1981; Gene expression in visna virus infection in sheep. Nature, London 292:240–242
    [Google Scholar]
  7. Brassfield A. L., Adams D. S., Crawford T. B., McGuire T. C. 1982; Ultrastructure of arthritis induced by a caprine retrovirus. Arthritis and Rheumatism 25:930–936
    [Google Scholar]
  8. Cheevers W. P., Roberson S., Klevjer-Anderson P., Crawford T. B. 1981; Characterization of caprine arthritis-encephalitis virus: a new retrovirus of goats. Archives of Virology 67:111–117
    [Google Scholar]
  9. Cork L. C., Narayan O. 1980; The pathogenesis of viral leukoencephalitis-arthritis of goats. I. Persistent viral infection with progressive pathological changes. Laboratory Investigation 42:596–602
    [Google Scholar]
  10. Cork L. C., Hadlow W. J., Crawford T. B., Gorham J. R., Piper R. C. 1974; Infectious leuko-encephalomyelitis of young goats. Journal of Infectious Diseases 129:134–141
    [Google Scholar]
  11. Crawford T. B., Adams D. S., Cheevers W. P., Cork L. C. 1980; Chronic arthritis in goats caused by a retrovirus. Science 207:997–999
    [Google Scholar]
  12. Crumpacker C. S. 1980; Viral glycoproteins in infectious disease processes. Reviews of Infectious Diseases 2:78–103
    [Google Scholar]
  13. Dubois-Dalcq M., Narayan O., Griffin D. E. 1979; Cell surface changes associated with mutation of visna virus in antibody-treated cell cultures. Virology 92:353–356
    [Google Scholar]
  14. Johnson G. C., Barbet A. F., Klevjer-Anderson P., McGuire T. C. 1983; Preferential immune response to virion-surface glycoproteins by caprine arthritis-encephalitis virus-infected goats. Infection and Immunity 41:657–665
    [Google Scholar]
  15. Klevjer-Anderson P., Anderson L. W. 1982; Caprine arthritis-encephalitis virus infection of caprine monocytes. Journal of General Virology 58:195–198
    [Google Scholar]
  16. Klevjer-Anderson P., Cheevers W. P. 1981; Characterization of the infection of caprine synovial membrane cells by the retrovirus caprine arthritis-encephalitis virus. Virology 110:113–119
    [Google Scholar]
  17. Klevjer-Anderson P., McGuire T. C. 1982; Neutralizing antibody response of rabbits and goats to the retrovirus, caprine arthritis-encephalitis virus. Infection and Immunity 38:455–461
    [Google Scholar]
  18. Kono Y., Kobayashi K., Fukynaga Y. 1973; Antigenic drift of equine infectious anemia virus in chronically infected horses. Archiv für die gesamte Virusforschung 41:1–10
    [Google Scholar]
  19. Malawista S. E., Steere A. C. 1981; Viral arthritis. In Textbook of Rheumatology Chapter 98 pp 1586–1601 Edited by Kelley W. N., Harris E. D., Ruddy S., Sledge C. B. Philadelphia: W. B. Saunders;
    [Google Scholar]
  20. Marmion B. P., McKay J. M. 1978; Rheumatoid arthritis and the virus hypothesis. In Experimental Models of Chronic Inflammatory Disease, Bayer Symposium VI pp 188–211 Edited by Glynn L. E., Schlumberger H. D. New York: Springer-Verlag;
    [Google Scholar]
  21. Roberson S. A., McGuire T. C., Klevjer-Anderson P., Gorham J. R., Cheevers W. P. 1982; Caprine arthritis-encephalitis virus is distinct from visna and progressive pneumonia viruses as measured by genome sequence homology. Journal of Virology 44:754–757
    [Google Scholar]
  22. Scott J. V., Stowring L., Haase A. T., Narayan O., Vigne R. 1979; Antigenic variation in visna virus. Cell 18:321–327
    [Google Scholar]
  23. Simpson R. W., McGinty L., Simon L., Smith C. A., Godzeski C. W., Boyd R. J. 1984; Association of parvoviruses with rheumatoid arthritis of humans. Science 223:1425–1428
    [Google Scholar]
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