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Volume 168, Issue 4

Role of horizontally transferred copper resistance genes in and Open Access

Abstract

Bacteria have evolved mechanisms which enable them to control intracellular concentrations of metals. In the case of transition metals, such as copper, iron and zinc, bacteria must ensure enough is available as a cofactor for enzymes whilst at the same time preventing the accumulation of excess concentrations, which can be toxic. Interestingly, metal homeostasis and resistance systems have been found to play important roles in virulence. This review will discuss the copper homeostasis and resistance systems in and and the implications that acquisition of additional copper resistance genes may have in these pathogens.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): CopA , CopL , copper , CopX , L. monocytogenes , plasmids , Staphylococcus aureus and USA300
Funding
This study was supported by the:
  • Biotechnology and Biological Sciences Research Council (Award BB/S006818/1)
    • Principle Award Recipient: JulieA. Morrissey
© 2022 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2022-04-11
2024-05-05
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Role of horizontally transferred copper resistance genes in Staphylococcus aureus and Listeria monocytogenes
Microbiology 168, 001162 (2022); https://doi.org/10.1099/mic.0.001162
/content/journal/micro/10.1099/mic.0.001162
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