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Volume 167, Issue 12

Orchestrating a heist: uptake and storage of metals by apicomplexan parasites Free

Abstract

The acquisition and storage of metals has been a preoccupation of life for millennia. Transition metals, in particular iron, copper and zinc, have vital roles within cells. However, metals also make dangerous cargos; inappropriate uptake or storage of transition metals leads to cell death. This paradox has led to cells developing elegant and frequently redundant mechanisms for fine-tuning local metal concentrations. In the context of infection, pathogens must overcome further hurdles, as hosts act to weaponize metal availability to prevent pathogen colonization and spread. Here, we detail the methods used by the Apicomplexa, a large family of eukaryotic parasites, to obtain and store essential metals.

  • Received:
  • Accepted:
  • Published Online:
Funding
This study was supported by the:
  • Carnegie Dunfermline Trust (Award RIG009880)
    • Principle Award Recipient: ClareR Harding
  • Wellcome Trust (Award 213455/Z/18/Z)
    • Principle Award Recipient: ClareR Harding
© 2021 The Authors
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2021-12-13
2024-05-05
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Orchestrating a heist: uptake and storage of metals by apicomplexan parasites
Microbiology 167, 001114 (2021); https://doi.org/10.1099/mic.0.001114
/content/journal/micro/10.1099/mic.0.001114
/content/journal/micro/10.1099/mic.0.001114
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