1887

Abstract

This is the first case report of septic abortion due to β-lactamase-negative ampicillin-resistant (BLNAR) non-typeable infection. In Japan, BLNAR is widespread and has become a clinical concern, especially in paediatrics and otolaryngology, but has not been previously recognized as a causative agent of obstetric or gynaecological infection.

A 31-year-old pregnant woman presented at 17 weeks and 6 days of gestation with a high fever; she was admitted with a diagnosis of threatened premature delivery. Despite tocolytic treatment, she aborted spontaneously 2 h after admission and then entered septic shock. BLNAR was detected in both blood and vaginal cultures. Her condition gradually improved after several days of treatment with cefotaxime, and she was ultimately discharged without sequelae or complaints.

Although penicillin with a β-lactamase inhibitor is currently recommended for the treatment of septic abortion, this combination will probably lead to treatment failure in the case of BLNAR infection. As this study reveals, can cause septic abortion; hence, future efforts should be undertaken to detect and therapeutically target this pathogen during pregnancy.

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2017-10-16
2024-03-28
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