1887

Abstract

Influenza B virus remains a major cause of respiratory diseases worldwide. Because of limited epidemiological and genetic data, the local and global transmission patterns of influenza B virus are not fully understood. Here we report the molecular and phylogenetic characterization of 163 influenza B virus isolates from pediatric inpatients with influenza-like illness in the winter of 2011–2012 in South Korea. Analysis of haemagglutinin and neuraminidase genes of the influenza B isolates revealed that both B/Victoria (62 %) and B/Yamagata lineages (38 %) co-circulated during that influenza season, and a considerable number of the isolates carried several amino acid substitutions in the four major antigenic epitopes of their haemagglutinin protein.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/jgv.0.000983
2017-12-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/98/12/2950.html?itemId=/content/journal/jgv/10.1099/jgv.0.000983&mimeType=html&fmt=ahah

References

  1. Sullivan KM, Monto AS, Longini IM. Estimates of the US health impact of influenza. Am J Public Health 1993; 83:1712–1716 [View Article][PubMed]
    [Google Scholar]
  2. Review of the 2011–2012 winter influenza season, northern hemisphere. Wkly Epidemiol Rec 2012; 87:233–240[PubMed]
    [Google Scholar]
  3. Lal SK, Chow VT. Avian influenza H5N1 virus: an emerging global pandemic. In Emerging Viral Diseases of Southeast Asia Basel, Switzerland: Karger Publishers; 2007 pp. 59–77
    [Google Scholar]
  4. Dawood FS, Jain S, Finelli L, Shaw MW, Lindstrom S et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009; 360:2605–2615 [View Article][PubMed]
    [Google Scholar]
  5. Peltola V, Ziegler T, Ruuskanen O. Influenza A and B virus infections in children. Clin Infect Dis 2003; 36:299–305 [View Article][PubMed]
    [Google Scholar]
  6. Usonis V, Anca I, André F, Chlibek R, Ivaskeviciene I et al. Central European Vaccination Advisory Group (CEVAG) guidance statement on recommendations for influenza vaccination in children. BMC Infect Dis 2010; 10:168 [View Article][PubMed]
    [Google Scholar]
  7. Ruf BR, Knuf M. The burden of seasonal and pandemic influenza in infants and children. Eur J Pediatr 2014; 173:265–276 [View Article][PubMed]
    [Google Scholar]
  8. Olson DR, Heffernan RT, Paladini M, Konty K, Weiss D et al. Monitoring the impact of influenza by age: emergency department fever and respiratory complaint surveillance in New York city. PLoS Med 2007; 4:e247 [View Article][PubMed]
    [Google Scholar]
  9. Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y. Evolution and ecology of influenza A viruses. Microbiol Rev 1992; 56:152–179[PubMed]
    [Google Scholar]
  10. Yen HL, Webster RG. Pandemic influenza as a current threat. Curr Top Microbiol Immunol 2009; 333:3–24 [View Article][PubMed]
    [Google Scholar]
  11. Treanor J. Influenza vaccine–outmaneuvering antigenic shift and drift. N Engl J Med 2004; 350:218–220 [View Article][PubMed]
    [Google Scholar]
  12. Cox NJ, Bender CA. The molecular epidemiology of influenza viruses. Semin Virol 1995; 6:359–370 [View Article]
    [Google Scholar]
  13. Nerome R, Hiromoto Y, Sugita S, Tanabe N, Ishida M et al. Evolutionary characteristics of influenza B virus since its first isolation in 1940: dynamic circulation of deletion and insertion mechanism. Arch Virol 1998; 143:1569–1583 [View Article][PubMed]
    [Google Scholar]
  14. Kanegae Y, Sugita S, Endo A, Ishida M, Senya S et al. Evolutionary pattern of the hemagglutinin gene of influenza B viruses isolated in Japan: cocirculating lineages in the same epidemic season. J Virol 1990; 64:2860–2865[PubMed]
    [Google Scholar]
  15. Rota PA, Wallis TR, Harmon MW, Rota JS, Kendal AP et al. Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983. Virology 1990; 175:59–68 [View Article][PubMed]
    [Google Scholar]
  16. Beran J, Wertzova V, Honegr K, Kaliskova E, Havlickova M et al. Challenge of conducting a placebo-controlled randomized efficacy study for influenza vaccine in a season with low attack rate and a mismatched vaccine B strain: a concrete example. BMC Infect Dis 2009; 9:2 [View Article][PubMed]
    [Google Scholar]
  17. Skowronski DM, Janjua NZ, Sabaiduc S, De Serres G, Winter AL et al. Influenza A/subtype and B/lineage effectiveness estimates for the 2011–2012 trivalent vaccine: cross-season and cross-lineage protection with unchanged vaccine. J Infect Dis 2014; 210:126–137 [View Article][PubMed]
    [Google Scholar]
  18. Belshe RB. The need for quadrivalent vaccine against seasonal influenza. Vaccine 2010; 28:D45–D53 [View Article][PubMed]
    [Google Scholar]
  19. Ambrose CS, Levin MJ. The rationale for quadrivalent influenza vaccines. Hum Vaccin Immunother 2012; 8:81–88 [View Article][PubMed]
    [Google Scholar]
  20. Hoffmann E, Mahmood K, Yang CF, Webster RG, Greenberg HB et al. Rescue of influenza B virus from eight plasmids. Proc Natl Acad Sci USA 2002; 99:11411–11416 [View Article][PubMed]
    [Google Scholar]
  21. Stockton J, Ellis JS, Saville M, Clewley JP, Zambon MC. Multiplex PCR for typing and subtyping influenza and respiratory syncytial viruses. J Clin Microbiol 1998; 36:2990–2995[PubMed]
    [Google Scholar]
  22. Sheu TG, Deyde VM, Garten RJ, Klimov AI, Gubareva LV. Detection of antiviral resistance and genetic lineage markers in influenza B virus neuraminidase using pyrosequencing. Antiviral Res 2010; 85:354–360 [View Article][PubMed]
    [Google Scholar]
  23. Ali G, Amer HM, Almajhdi FN. Hemagglutinin and neuraminidase genes of influenza B viruses circulating in Riyadh, Saudi Arabia during 2010–2011: evolution and sequence analysis. J Med Virol 2014; 86:1003–1016 [View Article][PubMed]
    [Google Scholar]
  24. Higgins DG, Bleasby AJ, Fuchs R. CLUSTAL V: improved software for multiple sequence alignment. Comput Appl Biosci 1992; 8:189–191 [View Article][PubMed]
    [Google Scholar]
  25. Perrière G, Gouy M. WWW-query: an on-line retrieval system for biological sequence banks. Biochimie 1996; 78:364–369 [View Article][PubMed]
    [Google Scholar]
  26. Shen J, Kirk BD, Ma J, Wang Q. Diversifying selective pressure on influenza B virus hemagglutinin. J Med Virol 2009; 81:114–124 [View Article][PubMed]
    [Google Scholar]
  27. Wang Q, Cheng F, Lu M, Tian X, Ma J. Crystal structure of unliganded influenza B virus hemagglutinin. J Virol 2008; 82:3011–3020 [View Article][PubMed]
    [Google Scholar]
  28. Verhoeyen M, van Rompuy L, Jou WM, Huylebroeck D, Fiers W. Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 hemagglutinin. Nucleic Acids Res 1983; 11:4703–4712 [View Article][PubMed]
    [Google Scholar]
  29. McCullers JA, Wang GC, He S, Webster RG. Reassortment and insertion-deletion are strategies for the evolution of influenza B viruses in nature. J Virol 1999; 73:7343–7348[PubMed]
    [Google Scholar]
  30. Arvia R, Corcioli F, Pierucci F, Azzi A. Molecular markers of influenza B lineages and clades. Viruses 2014; 6:4437–4446 [View Article][PubMed]
    [Google Scholar]
  31. Fang Q, Gao Y, Chen M, Guo X, Yang X et al. Molecular epidemiology and evolution of influenza A and B viruses during winter 2013–2014 in Beijing, China. Arch Virol 2015; 160:1083–1095 [View Article][PubMed]
    [Google Scholar]
  32. Couch RB. Prevention and treatment of influenza. N Engl J Med 2000; 343:1778–1787 [View Article][PubMed]
    [Google Scholar]
  33. Burnham AJ, Baranovich T, Govorkova EA. Neuraminidase inhibitors for influenza B virus infection: efficacy and resistance. Antiviral Res 2013; 100:520–534 [View Article][PubMed]
    [Google Scholar]
  34. Burnham AJ, Baranovich T, Marathe BM, Armstrong J, Webster RG et al. Fitness costs for Influenza B viruses carrying neuraminidase inhibitor-resistant substitutions: underscoring the importance of E119A and H274Y. Antimicrob Agents Chemother 2014; 58:2718–2730 [View Article][PubMed]
    [Google Scholar]
  35. Oakley AJ, Barrett S, Peat TS, Newman J, Streltsov VA et al. Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses. J Med Chem 2010; 53:6421–6431 [View Article][PubMed]
    [Google Scholar]
  36. Yen HL, Hoffmann E, Taylor G, Scholtissek C, Monto AS et al. Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses. J Virol 2006; 80:8787–8795 [View Article][PubMed]
    [Google Scholar]
  37. Chan PK, Chan MC, Cheung JL, Lee N, Leung TF et al. Influenza B lineage circulation and hospitalization rates in a subtropical city, Hong Kong, 2000-2010. Clin Infect Dis 2013; 56:677–684 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/jgv.0.000983
Loading
/content/journal/jgv/10.1099/jgv.0.000983
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error