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Volume 98, Issue 4

Novel bat adenoviruses with low G+C content shed new light on the evolution of adenoviruses Free

Abstract

Bats have been reported to carry diverse adenoviruses. However, most bat adenoviruses have been identified on the basis of partial genome sequences, and knowledge on the evolution of bat adenoviruses remains limited. In this study, we isolated and characterized four novel adenoviruses from two distinct bat species, and their full-length genomes were sequenced. Sequence analysis revealed that these isolates represented three distinct species of the genus . However, all isolates had an exceptionally low G+C content and relatively short genomes compared with other known mastadenoviruses. We further analysed the relationships among the G+C content, 5′-C-phosphate-G-3′ (CpG) representation and genome size in the family . Our results revealed that the CpG representation in adenoviral genomes depends primarily on the level of methylation, and the genome size displayed significant positive correlations with both G+C content and CpG representation. Since ancestral adenoviruses are believed to have contained short genomes, those probably had a low G+C content, similar to the genomes of these bat strains. Our results suggest that bats are important natural reservoirs for adenoviruses and play important roles in the evolution of adenoviruses.

  • Received:
  • Accepted:
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Keyword(s): base composition , bat adenovirus , CpG methylation , G+C content and genome length
© 2017 The Authors
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2017-04-01
2024-05-21
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Novel bat adenoviruses with low G+C content shed new light on the evolution of adenoviruses
J. Gen. Virol. 98, 739 (2017); https://doi.org/10.1099/jgv.0.000739
/content/journal/jgv/10.1099/jgv.0.000739
/content/journal/jgv/10.1099/jgv.0.000739
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